Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.V217V

c.651G>A

Surrounding Variants

3 papers

NM_000546.6

p.V217V

c.651G>T

1 paper

NM_000546.6

p.V217_V218ins1

c.651_652insATG

4 papers

NM_000546.6

p.V217fs

c.649_650fs

1 paper

NM_000546.6

p.V217V

c.651G>C

1 paper

NM_000546.6

p.V217delins

c.650_651delinsGT

1 paper

NM_000546.6

p.V217delFs

c.650delA

1 paper

NM_000546.6

p.V216_V217delins

c.646_651delinsTTGGGT

1 paper

NM_000546.6

p.H214_V217del0

c.642_650del9

1 paper

NM_000546.6

p.R213_V217delFs

c.637_650del14

1 paper

NM_000546.6

p.T211_V217delFs

c.633_649del17

1 paper

NM_000546.6

p.V216_V217insFs

c.648_649dupGG

29 papers

NM_000546.6

p.V217G

c.650T>G