Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

18 papers

NM_000546.6

p.V217L

c.649G>T

Surrounding Variants

9 papers

NM_000546.6

p.V217L

c.649G>C

34 papers

NM_000546.6

p.V217M

c.649G>A

8 papers

NM_000546.6

p.V217fs

c.649_650fs

4 papers

NM_000546.6

p.V216delFs

c.647_648delCA

2 papers

NM_000546.6

p.S215_V216del2

c.643_647del6

1 paper

NM_000546.6

p.V216_V217insFs

c.648_649dupGG

29 papers

NM_000546.6

p.V217G

c.650T>G

7 papers

NM_000546.6

p.V217A

c.650T>C

6 papers

NM_000546.6

p.V217E

c.650T>A

5 papers

NM_000546.6

p.V217delFs

c.649delC

1 paper

NM_000546.6

p.S215_V217del0

c.644_649del6

4 papers

NM_000546.6

p.V216V

c.648G>T