Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.V216V

c.648G>T

Surrounding Variants

1 paper

NM_000546.6

p.S215_V216insFs

c.643_647dup5

1 paper

NM_000546.6

p.R213_V216ins1

c.639_647dup9

2 papers

NM_000546.6

p.V216_V217insFs

c.648_649ins4

5 papers

NM_000546.6

p.V216fs

c.646_647fs

3 papers

NM_000546.6

p.V216V

c.648G>C

4 papers

NM_000546.6

p.V216V

c.648G>A

39 papers

NM_000546.6

p.V216G

c.647T>G

9 papers

NM_000546.6

p.V216A

c.647T>C

27 papers

NM_000546.6

p.V216E

c.647T>A

18 papers

NM_000546.6

p.V217L

c.649G>T

9 papers

NM_000546.6

p.V217L

c.649G>C

34 papers

NM_000546.6

p.V217M

c.649G>A