Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.S215del1

c.643_644delACT

Surrounding Variants

87 papers

NM_000546.6

p.V216L

c.646G>T

NM_001276760.3

p.V177L

c.529G>T

1 paper

NM_000546.6

p.S215ins0

c.643_645dupAGT

8 papers

NM_000546.6

p.V216_V217insC

c.646_650ins3

1 paper

NM_000546.6

p.V216_V217ins4

c.646_650ins12

1 paper

NM_000546.6

p.V216ins1

c.646_647insTTA

1 paper

NM_000546.6

p.V216insFs

c.646_647ins4

83 papers

NM_000546.6

p.V216L

c.646G>C

NM_001276760.3

p.V177L

c.529G>C

363 papers

NM_000546.6

p.V216M

c.646G>A

8 papers

NM_000546.6

p.S215delFs

c.645delA

5 papers

NM_000546.6

p.V216fs

c.646_647fs

1 paper

NM_000546.6

p.L206_S215del10

c.616_644del30

1 paper

NM_000546.6

p.Y205_S215delFs

c.614_645del32