Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S215delFs

c.643_644delCT

Surrounding Variants

2 papers

NM_000546.6

p.S215insFs

c.643_644dupAG

1 paper

NM_000546.6

p.S215_V216insFs

c.645_646insC

8 papers

NM_000546.6

p.S215fs

c.643_644fs

141 papers

NM_000546.6

p.S215R

c.645T>G

1 paper

NM_000546.6

p.S215S

c.645T>C

141 papers

NM_000546.6

p.S215R

c.645T>A

1 paper

NM_000546.6

p.S215delFs

c.644delC

136 papers

NM_000546.6

p.S215I

c.644G>T

NM_001126118.2

p.S176I

c.527G>T

87 papers

NM_000546.6

p.V216L

c.646G>T

NM_001276760.3

p.V177L

c.529G>T

1 paper

NM_000546.6

p.S215ins0

c.643_645dupAGT

8 papers

NM_000546.6

p.V216_V217insC

c.646_650ins3

1 paper

NM_000546.6

p.V216_V217ins4

c.646_650ins12