Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.S215delFs

c.643delT

Surrounding Variants

136 papers

NM_000546.6

p.S215I

c.644G>T

NM_001126118.2

p.S176I

c.527G>T

3 papers

NM_000546.6

p.S215insFs

c.643dupA

34 papers

NM_000546.6

p.S215T

c.644G>C

87 papers

NM_000546.6

p.S215N

c.644G>A

NM_001126118.2

p.S176N

c.527G>A

13 papers

NM_000546.6

p.H214_S215delFs

c.642_643delTA

1 paper

NM_000546.6

p.T211_S215del0

c.632_643del12

1 paper

NM_000546.6

p.L206_S215del0

c.617_643del27

2 papers

NM_000546.6

p.S215insFs

c.643_644dupAG

1 paper

NM_000546.6

p.S215_V216insFs

c.645_646insC

8 papers

NM_000546.6

p.S215fs

c.643_644fs

141 papers

NM_000546.6

p.S215R

c.645T>G

1 paper

NM_000546.6

p.S215S

c.645T>C