Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

126 papers

NM_000546.6

p.S215G

c.643A>G

Surrounding Variants

17 papers

NM_000546.6

p.S215fs

c.643_644fs

12 papers

NM_000546.6

p.S215C

c.643A>T

140 papers

NM_000546.6

p.S215R

c.643A>C

1 paper

NM_000546.6

p.H214insFs

c.642dupT

7 papers

NM_000546.6

p.S215_V216insG

c.643_647ins3

1 paper

NM_000546.6

p.S215_V216ins5

c.643_647ins15

1 paper

NM_000546.6

p.S215_V216ins7

c.643_647ins21

1 paper

NM_000546.6

p.S215insFs

c.643_644insTA

2 papers

NM_000546.6

p.H214delFs

c.642delA

1 paper

NM_000546.6

p.H214del1

c.640_641delATG

1 paper

NM_000546.6

p.F212_H214delFs

c.636_642del7

2 papers

NM_000546.6

p.F212_H214del0

c.634_642del9