Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R213del1

c.637_638delTCG

Surrounding Variants

26 papers

NM_000546.6

p.H214L

c.641A>T

301 papers

NM_000546.6

p.H214R

c.641A>G

NM_001126118.2

p.H175R

c.524A>G

17 papers

NM_000546.6

p.H214P

c.641A>C

1 paper

NM_000546.6

p.H214delFs

c.640delG

1 paper

NM_000546.6

p.H214_S215insFs

c.642_643insAG

16 papers

NM_000546.6

p.H214fs

c.640_641fs

1 paper

NM_000546.6

p.H214_S215ins2

c.642_643ins6

1 paper

NM_000546.6

p.H214insFs

c.640_641dupCA

26 papers

NM_000546.6

p.H214Q

c.642T>G

3 papers

NM_000546.6

p.H214H

c.642T>C

24 papers

NM_000546.6

p.H214Q

c.642T>A

6 papers

NM_000546.6

p.H214delFs

c.641delT