Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.H214_S215insG

c.640_644ins3

Surrounding Variants

22 papers

NM_000546.6

p.H214fs

c.640_641fs

29 papers

NM_000546.6

p.H214Y

c.640C>T

NM_001126118.2

p.H175Y

c.523C>T

13 papers

NM_000546.6

p.H214D

c.640C>G

1 paper

NM_000546.6

p.H214insFs

c.640_641insT

13 papers

NM_000546.6

p.H214N

c.640C>A

2 papers

NM_000546.6

p.R213delFs

c.639delT

2 papers

NM_000546.6

p.F212_R213del2

c.634_638del6

2 papers

NM_000546.6

p.N210_R213del0

c.628_639del12

1 paper

NM_000546.6

p.D207_R213delFs

c.621_639del19

26 papers

NM_000546.6

p.H214L

c.641A>T

301 papers

NM_000546.6

p.H214R

c.641A>G

NM_001126118.2

p.H175R

c.524A>G

79 papers

NM_000546.6

p.R213R

c.639A>G