Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

79 papers

NM_000546.6

p.R213R

c.639A>G

Surrounding Variants

1 paper

NM_000546.6

p.R213_H214insFs

c.639_640insC

25 papers

NM_000546.6

p.R213fs

c.637_638fs

NM_001126117.2

p.R81fs

c.241_242fs

NM_001126118.2

p.R174fs

c.520_521fs

NM_001276698.3

p.R54fs

c.160_161fs

1 paper

NM_000546.6

p.R213delins

c.638_639delinsAG

2 papers

NM_000546.6

p.R213delFs

c.638delC

4 papers

NM_000546.6

p.R213delins

c.637_639delinsTGG

1 paper

NM_000546.6

p.F212_R213delFs

c.635_638del4

22 papers

NM_000546.6

p.H214fs

c.640_641fs

180 papers

NM_000546.6

p.R213L

c.638G>T

1 paper

NM_000546.6

p.R213ins1

c.637_638insCAC

2 papers

NM_000546.6

p.R213insFs

c.638_639insA

70 papers

NM_000546.6

p.R213P

c.638G>C

357 papers

NM_000546.6

p.R213Q

c.638G>A

NM_001126115.2

p.R81Q

c.242G>A

NM_001126118.2

p.R174Q

c.521G>A