Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

918 papers

NM_000546.6

p.R213*

c.637C>T

NM_001126115.2

p.R81*

c.241C>T

Surrounding Variants

45 papers

NM_000546.6

p.R213G

c.637C>G

4 papers

NM_001276698.3

p.F53insFs

c.159dupT

NM_001126117.2

p.F80insFs

c.240dupT

NM_000546.6

p.F212insFs

c.636dupT

NM_001126118.2

p.F173insFs

c.519dupT

2 papers

NM_000546.6

p.R213_H214insT

c.637_641ins3

1 paper

NM_000546.6

p.R213_H214insGG

c.637_641ins6

2 papers

NM_000546.6

p.R213_H214ins5

c.637_641ins15

3 papers

NM_000546.6

p.R213R

c.637C>A

29 papers

NM_000546.6

p.F212delFs

c.636delA

28 papers

NM_000546.6

p.F212delFs

c.635_636delAA

1 paper

NM_000546.6

p.R209_F212del4

c.625_635del12

1 paper

NM_000546.6

p.E204_F212del9

c.610_635del27

25 papers

NM_000546.6

p.R213fs

c.637_638fs

35 papers

NM_000546.6

p.F212fs

c.634_635fs

NM_001126115.2

p.F80fs

c.238_239fs