Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

35 papers

NM_000546.6

p.F212fs

c.634_635fs

NM_001126115.2

p.F80fs

c.238_239fs

Surrounding Variants

8 papers

NM_000546.6

p.F212L

c.636T>G

9 papers

NM_000546.6

p.F212L

c.636T>A

1 paper

NM_000546.6

p.T211_F212delFs

c.632_635del4

1 paper

NM_000546.6

p.V203_F212del0

c.609_635del27

4 papers

NM_000546.6

p.F212C

c.635T>G

11 papers

NM_000546.6

p.F212S

c.635T>C

7 papers

NM_000546.6

p.F212Y

c.635T>A

2 papers

NM_000546.6

p.R209_F212delFs

c.625_634del10

1 paper

NM_000546.6

p.D208_F212del0

c.623_634del12

1 paper

NM_000546.6

p.D207_F212delFs

c.619_634del16

1 paper

NM_000546.6

p.L206_F212delFs

c.618_634del17

918 papers

NM_000546.6

p.R213*

c.637C>T

NM_001126115.2

p.R81*

c.241C>T