Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

30 papers

NM_000546.6

p.N210fs

c.628_629fs

Surrounding Variants

3 papers

NM_000546.6

p.N210N

c.630C>T

5 papers

NM_000546.6

p.N210K

c.630C>G

1 paper

NM_000546.6

p.N210insFs

c.629dupA

1 paper

NM_000546.6

p.N210_T211insFs

c.630_631ins7

6 papers

NM_000546.6

p.N210K

c.630C>A

11 papers

NM_000546.6

p.N210delFs

c.629delT

3 papers

NM_000546.6

p.R209_N210delFs

c.627_628delTT

2 papers

NM_000546.6

p.R209_N210delFs

c.625_628del4

2 papers

NM_000546.6

p.R209_N210delFs

c.625_629del5

12 papers

NM_000546.6

p.T211fs

c.631_632fs

9 papers

NM_000546.6

p.T211S

c.631A>T

5 papers

NM_000546.6

p.N210I

c.629A>T