Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.R209G

c.625A>G

Surrounding Variants

54 papers

NM_000546.6

p.R209*

c.625A>T

1 paper

NM_000546.6

p.R209R

c.625A>C

1 paper

NM_000546.6

p.R209_N210insG

c.625_629ins3

67 papers

NM_000546.6

p.R209fs

c.625_626fs

1 paper

NM_000546.6

p.D208_R209delins

c.624_625delinsTG

1 paper

NM_000546.6

p.D207_D208del2

c.619_623del6

1 paper

NM_000546.6

p.L206_D208delFs

c.618_624del7

1 paper

NM_000546.6

p.R196_D208del0

c.586_624del39

14 papers

NM_000546.6

p.R209I

c.626G>T

1 paper

NM_000546.6

p.R209insFs

c.625_626insAA

12 papers

NM_000546.6

p.R209T

c.626G>C

47 papers

NM_000546.6

p.R209K

c.626G>A