Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.D208E

c.624C>G

Surrounding Variants

3 papers

NM_000546.6

p.D208D

c.624C>T

1 paper

NM_000546.6

p.D208_R209insFs

c.624_625insTC

6 papers

NM_000546.6

p.D208fs

c.622_623fs

1 paper

NM_000546.6

p.D208insFs

c.623dupA

1 paper

NM_000546.6

p.D208insFs

c.622_623ins4

14 papers

NM_000546.6

p.D208E

c.624C>A

1 paper

NM_000546.6

p.D207_D208del1

c.621_623delTCA

1 paper

NM_000546.6

p.E204_D208del0

c.612_623del12

65 papers

NM_000546.6

p.D208V

c.623A>T

54 papers

NM_000546.6

p.R209*

c.625A>T

36 papers

NM_000546.6

p.D208G

c.623A>G

9 papers

NM_000546.6

p.R209G

c.625A>G