Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E204_D208delFs

c.612_622del11

Surrounding Variants

65 papers

NM_000546.6

p.D208V

c.623A>T

36 papers

NM_000546.6

p.D208G

c.623A>G

10 papers

NM_000546.6

p.D208A

c.623A>C

1 paper

NM_000546.6

p.V203_D207del5

c.607_620del15

15 papers

NM_000546.6

p.D208Y

c.622G>T

NM_001126118.2

p.D169delins

c.505_506delinsTA

1 paper

NM_000546.6

p.D208insFs

c.622_623insC

9 papers

NM_000546.6

p.D208H

c.622G>C

22 papers

NM_000546.6

p.D208N

c.622G>A

1 paper

NM_000546.6

p.D207_D208delins

c.621_622delinsCT

1 paper

NM_000546.6

p.Y205_D207del3

c.613_620del9

3 papers

NM_000546.6

p.D208D

c.624C>T

14 papers

NM_000546.6

p.D208E

c.624C>G