Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.D207E

c.621T>G

Surrounding Variants

8 papers

NM_000546.6

p.D207fs

c.619_620fs

5 papers

NM_000546.6

p.D207E

c.621T>A

1 paper

NM_000546.6

p.D207delFs

c.620delT

15 papers

NM_000546.6

p.D208Y

c.622G>T

NM_001126118.2

p.D169delins

c.505_506delinsTA

1 paper

NM_000546.6

p.D208insFs

c.622_623insC

9 papers

NM_000546.6

p.D208H

c.622G>C

22 papers

NM_000546.6

p.D208N

c.622G>A

1 paper

NM_000546.6

p.D207_D208delins

c.621_622delinsCT

1 paper

NM_000546.6

p.Y205_D207del3

c.613_620del9

4 papers

NM_000546.6

p.D208fs

c.622_623fs

6 papers

NM_000546.6

p.D207V

c.620A>T

13 papers

NM_000546.6

p.D207G

c.620A>G