Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D207_D208insT

c.619_623ins3

Surrounding Variants

6 papers

NM_000546.6

p.D207fs

c.619_620fs

12 papers

NM_000546.6

p.D207Y

c.619G>T

6 papers

NM_000546.6

p.D207H

c.619G>C

16 papers

NM_000546.6

p.D207N

c.619G>A

1 paper

NM_000546.6

p.L206_D207Fs

c.618_619delinsAFs

4 papers

NM_000546.6

p.Y205_L206del0

c.613_618del6

1 paper

NM_000546.6

p.R202_L206del0

c.604_618del15

1 paper

NM_000546.6

p.N200_L206del7

c.598_617del21

1 paper

NM_000546.6

p.R196_L206del11

c.586_617del33

8 papers

NM_000546.6

p.L206F

c.618G>T

1 paper

NM_000546.6

p.L206Fs

c.618delinsTTFs

1 paper

NM_000546.6

p.L206insFs

c.617dupT