Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

25 papers

NM_000546.6

p.Y205*

c.615T>G

Surrounding Variants

12 papers

NM_000546.6

p.Y205fs

c.613_614fs

1 paper

NM_000546.6

p.R196_Y205insFs

c.586_614dup29

1 paper

NM_000546.6

p.Y205insFs

c.614_615ins4

3 papers

NM_000546.6

p.Y205Y

c.615T>C

27 papers

NM_000546.6

p.Y205*

c.615T>A

1 paper

NM_000546.6

p.N200_Y205delFs

c.598_614del17

1 paper

NM_000546.6

p.L206insFs

c.616_617insG

1 paper

NM_000546.6

p.L206_D207insA

c.616_620ins3

1 paper

NM_000546.6

p.L206V

c.616T>G

3 papers

NM_000546.6

p.L206L

c.616T>C

4 papers

NM_000546.6

p.L206M

c.616T>A

1 paper

NM_000546.6

p.Y205delFs

c.614_615delAT