Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V203_E204delFs

c.607_611del5

Surrounding Variants

48 papers

NM_000546.6

p.Y205F

c.614A>T

275 papers

NM_000546.6

p.Y205C

c.614A>G

NM_001126115.2

p.Y73C

c.218A>G

52 papers

NM_000546.6

p.Y205S

c.614A>C

2 papers

NM_000546.6

p.Y205insFs

c.613dupT

1 paper

NM_000546.6

p.Y205ins1

c.614_615insGTA

1 paper

NM_000546.6

p.Y205delFs

c.613delA

1 paper

NM_000546.6

p.L201_Y205delFs

c.603_613del11

1 paper

NM_000546.6

p.Y205insFs

c.613_614insG

1 paper

NM_000546.6

p.Y205insFs

c.613_614insC

12 papers

NM_000546.6

p.Y205fs

c.613_614fs

1 paper

NM_000546.6

p.R196_Y205insFs

c.586_614dup29

1 paper

NM_000546.6

p.Y205insFs

c.614_615ins4