Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.Y205fs

c.613_614fs

Surrounding Variants

1 paper

NM_000546.6

p.Y205insFs

c.613_614insG

1 paper

NM_000546.6

p.Y205insFs

c.613_614insC

87 papers

NM_000546.6

p.Y205D

c.613T>G

87 papers

NM_000546.6

p.Y205H

c.613T>C

40 papers

NM_000546.6

p.Y205N

c.613T>A

2 papers

NM_000546.6

p.E204delFs

c.611_612delCT

2 papers

NM_000546.6

p.E204del1

c.610_611delCTC

1 paper

NM_000546.6

p.V203_E204del2

c.607_611del6

1 paper

NM_000546.6

p.R196_E204delFs

c.588_612del25

1 paper

NM_000546.6

p.I195_E204del10

c.583_611del30

1 paper

NM_000546.6

p.A189_E204del16

c.565_611del48

10 papers

NM_000546.6

p.E204D

c.612G>T