Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E204_Y205insFs

c.612_613insA

Surrounding Variants

10 papers

NM_000546.6

p.E204D

c.612G>T

1 paper

NM_000546.6

p.E204_Y205insFs

c.612_613insC

9 papers

NM_000546.6

p.E204fs

c.610_611fs

9 papers

NM_000546.6

p.E204D

c.612G>C

9 papers

NM_000546.6

p.E204E

c.612G>A

3 papers

NM_000546.6

p.E198_E204del0

c.594_611del18

1 paper

NM_000546.6

p.Y205insFs

c.613_614insG

1 paper

NM_000546.6

p.Y205insFs

c.613_614insC

87 papers

NM_000546.6

p.Y205D

c.613T>G

87 papers

NM_000546.6

p.Y205H

c.613T>C

40 papers

NM_000546.6

p.Y205N

c.613T>A

2 papers

NM_000546.6

p.E204delFs

c.611_612delCT