Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

179 papers

NM_000546.6

p.E204*

c.610G>T

Surrounding Variants

2 papers

NM_000546.6

p.E204insFs

c.610_611insTG

2 papers

NM_000546.6

p.E204insFs

c.610_611ins7

1 paper

NM_000546.6

p.E204_Y205insAG

c.610_614ins6

12 papers

NM_000546.6

p.E204Q

c.610G>C

21 papers

NM_000546.6

p.E204K

c.610G>A

1 paper

NM_000546.6

p.V203_E204delins

c.609_610delinsTT

1 paper

NM_000546.6

p.V203delFs

c.608_609delCA

1 paper

NM_000546.6

p.R202_V203del2

c.604_608del6

24 papers

NM_000546.6

p.E204fs

c.610_611fs

2 papers

NM_000546.6

p.V203V

c.609G>T

1 paper

NM_000546.6

p.V203_E204insFs

c.609_610insC

7 papers

NM_000546.6

p.V203fs

c.607_608fs