Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R202R

c.606T>G

Surrounding Variants

8 papers

NM_000546.6

p.R202fs

c.604_605fs

3 papers

NM_000546.6

p.R202R

c.606T>C

1 paper

NM_000546.6

p.R202R

c.606T>A

1 paper

NM_000546.6

p.R202delFs

c.605delC

43 papers

NM_000546.6

p.V203L

c.607G>T

16 papers

NM_000546.6

p.R202L

c.605G>T

1 paper

NM_000546.6

p.V203_E204ins7

c.607_611ins21

40 papers

NM_000546.6

p.V203L

c.607G>C

8 papers

NM_000546.6

p.R202P

c.605G>C

41 papers

NM_000546.6

p.V203M

c.607G>A

35 papers

NM_000546.6

p.R202H

c.605G>A

1 paper

NM_000546.6

p.R202delFs

c.606delA