Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.R202G

c.604C>G

Surrounding Variants

3 papers

NM_000546.6

p.R202fs

c.604_605fs

40 papers

NM_000546.6

p.R202C

c.604C>T

2 papers

NM_000546.6

p.L201insFs

c.603dupG

1 paper

NM_000546.6

p.G199_L201insFs

c.597_603dup7

1 paper

NM_000546.6

p.R202_V203insT

c.604_608ins3

12 papers

NM_000546.6

p.R202S

c.604C>A

3 papers

NM_000546.6

p.L201delFs

c.603delC

1 paper

NM_000546.6

p.N200_L201del2

c.598_602del6

16 papers

NM_000546.6

p.R202L

c.605G>T

12 papers

NM_000546.6

p.L201F

c.603G>T

1 paper

NM_000546.6

p.L201Fs

c.603delinsTTFs

8 papers

NM_000546.6

p.L201insFs

c.602_603insT