Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.L201F

c.603G>C

Surrounding Variants

12 papers

NM_000546.6

p.L201F

c.603G>T

1 paper

NM_000546.6

p.L201Fs

c.603delinsTTFs

8 papers

NM_000546.6

p.L201insFs

c.602_603insT

1 paper

NM_000546.6

p.N200_L201insFs

c.600_601dupTT

16 papers

NM_000546.6

p.L201fs

c.601_602fs

1 paper

NM_000546.6

p.L201_R202insFs

c.603_604insAA

3 papers

NM_000546.6

p.L201L

c.603G>A

13 papers

NM_000546.6

p.N200delFs

c.600delA

3 papers

NM_000546.6

p.L201delFs

c.601_602delAA

1 paper

NM_000546.6

p.N200_L201delFs

c.599_602del4

1 paper

NM_000546.6

p.E198_L201del0

c.594_602del9

1 paper

NM_000546.6

p.I195_L201del0

c.585_602del18