Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

39 papers

NM_000546.6

p.L201*

c.602T>A

Surrounding Variants

1 paper

NM_000546.6

p.L201W

c.602T>G

4 papers

NM_000546.6

p.L201S

c.602T>C

1 paper

NM_000546.6

p.V197_L201delFs

c.591_601del11

3 papers

NM_000546.6

p.L201V

c.601T>G

2 papers

NM_000546.6

p.L201M

c.601T>A

2 papers

NM_000546.6

p.N200del1

c.598_599delATT

1 paper

NM_000546.6

p.G199_N200delFs

c.597_600del4

1 paper

NM_000546.6

p.G199_N200del2

c.595_599del6

1 paper

NM_000546.6

p.V197_N200delFs

c.591_600del10

1 paper

NM_000546.6

p.I195_N200del0

c.583_600del18

1 paper

NM_000546.6

p.L194_N200del0

c.580_600del21

12 papers

NM_000546.6

p.L201F

c.603G>T