Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.N200S

c.599A>G

Surrounding Variants

6 papers

NM_000546.6

p.N200I

c.599A>T

4 papers

NM_000546.6

p.N200T

c.599A>C

2 papers

NM_000546.6

p.G199_N200del1

c.596_598delTTC

2 papers

NM_000546.6

p.G199_N200delFs

c.595_598del4

1 paper

NM_000546.6

p.I195_N200del0

c.584_598del15

1 paper

NM_000546.6

p.P191_N200delFs

c.573_598del26

15 papers

NM_000546.6

p.N200fs

c.598_599fs

3 papers

NM_000546.6

p.N200insFs

c.599dupA

1 paper

NM_000546.6

p.N200insFs

c.599_600ins14

1 paper

NM_000546.6

p.G199_N200ins0

c.597_599dupAAA

3 papers

NM_000546.6

p.N200K

c.600T>G

3 papers

NM_000546.6

p.N200K

c.600T>A