Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E198_G199del2

c.592_596del6

Surrounding Variants

16 papers

NM_000546.6

p.N200fs

c.598_599fs

11 papers

NM_000546.6

p.N200Y

c.598A>T

11 papers

NM_000546.6

p.N200D

c.598A>G

1 paper

NM_000546.6

p.N200H

c.598A>C

1 paper

NM_000546.6

p.N200_L201insC

c.598_602ins3

1 paper

NM_000546.6

p.G199_N200delins

c.596_598delinsGGG

1 paper

NM_000546.6

p.G199_N200delins

c.596_598delinsTAT

1 paper

NM_000546.6

p.G199delFs

c.596_597delTC

1 paper

NM_000546.6

p.E198_G199del1

c.594_596delCCT

6 papers

NM_000546.6

p.N200I

c.599A>T

2 papers

NM_000546.6

p.G199G

c.597A>T

8 papers

NM_000546.6

p.N200S

c.599A>G