Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E198insFs

c.593dupA

Surrounding Variants

27 papers

NM_000546.6

p.G199*

c.595G>T

21 papers

NM_000546.6

p.G199R

c.595G>C

23 papers

NM_000546.6

p.G199R

c.595G>A

3 papers

NM_000546.6

p.E198delFs

c.594delT

1 paper

NM_000546.6

p.H193_E198delFs

c.578_594del17

10 papers

NM_000546.6

p.G199fs

c.595_596fs

90 papers

NM_000546.6

p.G199V

c.596G>T

5 papers

NM_000546.6

p.G199A

c.596G>C

56 papers

NM_000546.6

p.G199E

c.596G>A

NM_001276698.3

p.G40E

c.119G>A

1 paper

NM_000546.6

p.E198del1

c.592_593delTTC

7 papers

NM_000546.6

p.E198D

c.594A>T

2 papers

NM_000546.6

p.E198E

c.594A>G