Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.E198D

c.594A>C

Surrounding Variants

7 papers

NM_000546.6

p.E198D

c.594A>T

2 papers

NM_000546.6

p.E198E

c.594A>G

8 papers

NM_000546.6

p.E198fs

c.592_593fs

1 paper

NM_000546.6

p.E198_G199insFs

c.594_595ins14

1 paper

NM_000546.6

p.H193_E198del0

c.579_593del15

27 papers

NM_000546.6

p.G199*

c.595G>T

1 paper

NM_000546.6

p.E198insFs

c.593dupA

21 papers

NM_000546.6

p.G199R

c.595G>C

23 papers

NM_000546.6

p.G199R

c.595G>A

3 papers

NM_000546.6

p.E198delFs

c.594delT

1 paper

NM_000546.6

p.H193_E198delFs

c.578_594del17

6 papers

NM_000546.6

p.E198V

c.593A>T