Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V197delins

c.589_590delinsAG

Surrounding Variants

40 papers

NM_000546.6

p.V197G

c.590T>G

8 papers

NM_000546.6

p.V197A

c.590T>C

31 papers

NM_000546.6

p.V197E

c.590T>A

2 papers

NM_000546.6

p.I195_V197delFs

c.585_589del5

37 papers

NM_000546.6

p.V197L

c.589G>T

1 paper

NM_000546.6

p.V197insFs

c.590dupT

1 paper

NM_000546.6

p.I195_V197ins1

c.584_589dup6

2 papers

NM_000546.6

p.V197fs

c.589_590fs

1 paper

NM_000546.6

p.R196insFs

c.588dupA

39 papers

NM_000546.6

p.V197L

c.589G>C

86 papers

NM_000546.6

p.V197M

c.589G>A

4 papers

NM_000546.6

p.V197V

c.591G>A