Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

85 papers

NM_000546.6

p.R196Q

c.587G>A

Surrounding Variants

28 papers

NM_000546.6

p.R196L

c.587G>T

1 paper

NM_000546.6

p.R196insFs

c.587_588insT

2 papers

NM_000546.6

p.I195_R196insFs

c.585_586insC

121 papers

NM_000546.6

p.R196P

c.587G>C

6 papers

NM_000546.6

p.R196delFs

c.586delG

1 paper

NM_000546.6

p.I195_R196delFs

c.585_586delGG

1 paper

NM_000546.6

p.I195_R196delFs

c.583_586del4

1 paper

NM_000546.6

p.L194_R196del0

c.581_586del6

1 paper

NM_000546.6

p.P191_R196delFs

c.573_586del14

1 paper

NM_000546.6

p.P191_R196delFs

c.571_586del16

1 paper

NM_000546.6

p.P190_R196delFs

c.570_586del17

1 paper

NM_000546.6

p.A189_R196delFs

c.567_586del20