Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R196insFs

c.586_587insAA

Surrounding Variants

724 papers

NM_000546.6

p.R196*

c.586C>T

NM_001126115.2

p.R64*

c.190C>T

NM_001126118.2

p.R157*

c.469C>T

32 papers

NM_000546.6

p.R196G

c.586C>G

1 paper

NM_000546.6

p.R196insFs

c.586_587ins13

1 paper

NM_000546.6

p.R196insFs

c.586_587insAT

1 paper

NM_000546.6

p.R196insFs

c.586_587ins5

1 paper

NM_000546.6

p.R196_V197ins8

c.586_590ins24

3 papers

NM_000546.6

p.R196R

c.586C>A

7 papers

NM_000546.6

p.I195_R196delins

c.585_586delinsTT

1 paper

NM_000546.6

p.I195del1

c.583_584delGAT

4 papers

NM_000546.6

p.L194_I195delFs

c.581_585del5

1 paper

NM_000546.6

p.H193_I195delFs

c.579_585del7

8 papers

NM_000546.6

p.R196fs

c.586_587fs