Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.I195M

c.585C>G

Surrounding Variants

5 papers

NM_000546.6

p.I195I

c.585C>T

19 papers

NM_000546.6

p.I195fs

c.583_584fs

2 papers

NM_000546.6

p.I195I

c.585C>A

2 papers

NM_000546.6

p.I195delFs

c.584delA

1 paper

NM_000546.6

p.L194_I195Fs

c.582_585delinsATTFs

1 paper

NM_000546.6

p.I195ins2

c.584_585ins6

1 paper

NM_000546.6

p.I195insFs

c.584_585insC

4 papers

NM_000546.6

p.I195insFs

c.583dupA

53 papers

NM_000546.6

p.I195S

c.584T>G

439 papers

NM_000546.6

p.I195T

c.584T>C

104 papers

NM_000546.6

p.I195N

c.584T>A

3 papers

NM_000546.6

p.I195delFs

c.583delT