Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L194delins

c.581_582delinsCA

Surrounding Variants

1 paper

NM_000546.6

p.L194insFs

c.580_581dupCT

1 paper

NM_000546.6

p.L194_I195insFs

c.582_583insGG

7 papers

NM_000546.6

p.L194fs

c.580_581fs

1 paper

NM_000546.6

p.L194_I195insFs

c.582_583insA

6 papers

NM_000546.6

p.L194L

c.582T>C

2 papers

NM_000546.6

p.L194L

c.582T>A

2 papers

NM_000546.6

p.L194delFs

c.580_581delAG

280 papers

NM_000546.6

p.L194R

c.581T>G

NM_001126115.2

p.L62R

c.185T>G

68 papers

NM_000546.6

p.L194P

c.581T>C

54 papers

NM_000546.6

p.L194H

c.581T>A

1 paper

NM_000546.6

p.L194delFs

c.580delG

2 papers

NM_000546.6

p.Q192_L194del0

c.575_580del6