Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.H193Q

c.579T>G

Surrounding Variants

4 papers

NM_000546.6

p.H193fs

c.577_578fs

2 papers

NM_000546.6

p.H193H

c.579T>C

12 papers

NM_000546.6

p.H193Q

c.579T>A

1 paper

NM_000546.6

p.H193delFs

c.578delT

7 papers

NM_000546.6

p.Q192del1

c.574_575delCTG

1 paper

NM_000546.6

p.A189_H193delFs

c.566_578del13

9 papers

NM_000546.6

p.L194fs

c.580_581fs

225 papers

NM_000546.6

p.L194F

c.580C>T

5 papers

NM_000546.6

p.L194V

c.580C>G

1 paper

NM_000546.6

p.L194insFs

c.580_581insT

1 paper

NM_000546.6

p.L194insFs

c.580_581ins14

6 papers

NM_000546.6

p.L194I

c.580C>A