Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

444 papers

NM_000546.6

p.H193R

c.578A>G

Surrounding Variants

205 papers

NM_000546.6

p.H193L

c.578A>T

96 papers

NM_000546.6

p.H193P

c.578A>C

NM_001126116.2

p.H61P

c.182A>C

1 paper

NM_000546.6

p.H193delFs

c.577delG

1 paper

NM_000546.6

p.P191_Q192del2

c.571_575del6

1 paper

NM_000546.6

p.P191_H193delFs

c.571_577del7

1 paper

NM_000546.6

p.A189_H193delFs

c.567_577del11

1 paper

NM_000546.6

p.L188_Q192del5

c.562_575del15

4 papers

NM_000546.6

p.H193fs

c.577_578fs

12 papers

NM_000546.6

p.H193Q

c.579T>G

2 papers

NM_000546.6

p.H193H

c.579T>C

12 papers

NM_000546.6

p.H193Q

c.579T>A

1 paper

NM_000546.6

p.H193delFs

c.578delT