Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

57 papers

NM_000546.6

p.H193D

c.577C>G

Surrounding Variants

5 papers

NM_000546.6

p.H193fs

c.577_578fs

217 papers

NM_000546.6

p.H193Y

c.577C>T

1 paper

NM_000546.6

p.Q192insFs

c.576dupG

1 paper

NM_000546.6

p.H193_L194insA

c.577_581ins3

54 papers

NM_000546.6

p.H193N

c.577C>A

1 paper

NM_000546.6

p.Q192_H193delins

c.576_577delinsCA

1 paper

NM_000546.6

p.P190_Q192delFs

c.570_576del7

1 paper

NM_000546.6

p.G187_Q192delFs

c.560_576del17

17 papers

NM_000546.6

p.Q192H

c.576G>T

9 papers

NM_000546.6

p.Q192fs

c.574_575fs

2 papers

NM_000546.6

p.Q192insFs

c.575dupA

17 papers

NM_000546.6

p.Q192H

c.576G>C