Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

63 papers

NM_000546.6

p.P191del1

c.571_572delAGG

Surrounding Variants

9 papers

NM_000546.6

p.Q192L

c.575A>T

20 papers

NM_000546.6

p.Q192R

c.575A>G

4 papers

NM_000546.6

p.Q192P

c.575A>C

1 paper

NM_000546.6

p.Q192insFs

c.574_575insC

3 papers

NM_000546.6

p.Q192delFs

c.574delG

1 paper

NM_000546.6

p.A189_Q192delFs

c.567_574del8

17 papers

NM_000546.6

p.Q192H

c.576G>T

9 papers

NM_000546.6

p.Q192fs

c.574_575fs

2 papers

NM_000546.6

p.Q192insFs

c.575dupA

17 papers

NM_000546.6

p.Q192H

c.576G>C

5 papers

NM_000546.6

p.Q192Q

c.576G>A

2 papers

NM_000546.6

p.Q192delFs

c.575delT