Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.P191_Q192insFs

c.573_574insT

Surrounding Variants

5 papers

NM_000546.6

p.Q192fs

c.574_575fs

325 papers

NM_000546.6

p.Q192*

c.574C>T

3 papers

NM_000546.6

p.Q192E

c.574C>G

1 paper

NM_000546.6

p.Q192_H193insC

c.574_578ins3

9 papers

NM_000546.6

p.Q192K

c.574C>A

4 papers

NM_000546.6

p.P191delFs

c.573delA

1 paper

NM_000546.6

p.P191_Q192delins

c.572_574delinsTTT

2 papers

NM_000546.6

p.P190_P191delFs

c.570_573del4

1 paper

NM_000546.6

p.G187_P191delFs

c.560_573del14

1 paper

NM_000546.6

p.P191insFs

c.572_573insC

1 paper

NM_000546.6

p.P191insFs

c.572_573insCC

18 papers

NM_000546.6

p.P191fs

c.571_572fs