Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.P191T

c.571C>A

Surrounding Variants

15 papers

NM_000546.6

p.P191fs

c.571_572fs

15 papers

NM_000546.6

p.P191S

c.571C>T

NM_001126118.2

p.P152S

c.454C>T

3 papers

NM_000546.6

p.P191A

c.571C>G

1 paper

NM_000546.6

p.P190insFs

c.570dupT

1 paper

NM_000546.6

p.P190delFs

c.570delA

1 paper

NM_000546.6

p.A189_P190del2

c.565_569del6

1 paper

NM_000546.6

p.L188_P190delFs

c.564_570del7

3 papers

NM_000546.6

p.P190insFs

c.569dupC

18 papers

NM_000546.6

p.P190fs

c.568_569fs

1 paper

NM_000546.6

p.P190P

c.570T>G

3 papers

NM_000546.6

p.P190P

c.570T>C

19 papers

NM_000546.6

p.P190delFs

c.569delG