Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.L188delFs

c.562_563delAG

Surrounding Variants

1 paper

NM_000546.6

p.L188L

c.564G>T

7 papers

NM_000546.6

p.L188fs

c.562_563fs

1 paper

NM_000546.6

p.L188L

c.564G>C

4 papers

NM_000546.6

p.L188L

c.564G>A

4 papers

NM_000546.6

p.L188delFs

c.563delA

1 paper

NM_000546.6

p.L188Fs

c.562_564delinsAAFs

4 papers

NM_000546.6

p.L188R

c.563T>G

11 papers

NM_000546.6

p.L188P

c.563T>C

3 papers

NM_000546.6

p.L188Q

c.563T>A

4 papers

NM_000546.6

p.L188delFs

c.562delG

1 paper

NM_000546.6

p.L188delins

c.562_563delinsTA

11 papers

NM_000546.6

p.A189S

c.565G>T