Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.G187_L188insFs

c.561_562insA

Surrounding Variants

2 papers

NM_000546.6

p.G187G

c.561T>G

1 paper

NM_000546.6

p.G187G

c.561T>C

1 paper

NM_000546.6

p.G187G

c.561T>A

8 papers

NM_000546.6

p.G187delFs

c.560delC

2 papers

NM_000546.6

p.G187fs

c.559_560fs

23 papers

NM_000546.6

p.G187V

c.560G>T

1 paper

NM_000546.6

p.G187insFs

c.560_561ins49

6 papers

NM_000546.6

p.G187A

c.560G>C

26 papers

NM_000546.6

p.G187D

c.560G>A

13 papers

NM_000546.6

p.L188fs

c.562_563fs

2 papers

NM_000546.6

p.L188L

c.562C>T

6 papers

NM_000546.6

p.L188V

c.562C>G