Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G187Splc

c.560-3T>A

Surrounding Variants

9 papers

NM_000546.6

p.G187Splc

c.560-3T>G

1 paper

NM_000546.6

p.G187Splc

c.560-4T>C

20 papers

NM_000546.6

p.G187Splc

c.560-2A>T

26 papers

NM_000546.6

p.G187Splc

c.560-2A>G

18 papers

NM_000546.6

p.G187Splc

c.560-2A>C

29 papers

NM_000546.6

p.G187Splc

c.560-1G>T

40 papers

NM_000546.6

p.G187R

c.559G>C

134 papers

NM_000546.6

p.G187Splc

c.560-1G>A

2 papers

NM_000546.6

p.G187Splc

c.560-6T>C

2 papers

NM_000546.6

p.G187fs

c.559_560fs

23 papers

NM_000546.6

p.G187V

c.560G>T

1 paper

NM_000546.6

p.G187insFs

c.560_561ins49