Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.G187Splc

c.559+41C>T

Surrounding Variants

1 paper

NM_000546.6

p.G187Splc

c.560-40A>G

1 paper

NM_000546.6

p.G187Splc

c.559+43G>T

1 paper

NM_000546.6

p.G187Splc

c.559+25G>A

2 papers

NM_000546.6

p.G187Splc

c.559+24C>T

1 paper

NM_000546.6

p.G187Splc

c.560-22A>G

2 papers

NM_000546.6

p.G187Splc

c.559+20G>A

1 paper

NM_000546.6

p.G187Splc

c.560-17T>A

2 papers

NM_000546.6

p.G187Splc

c.560-15A>C

1 paper

NM_000546.6

p.G187Splc

c.560-14C>A

2 papers

NM_000546.6

p.G187Splc

c.559+13G>A

1 paper

NM_000546.6

p.G187Splc

c.560-9T>G

1 paper

NM_000546.6

p.G187Splc

c.560-9T>A