Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

16 papers

NM_000546.6

p.G187Splc

c.559+2T>G

Surrounding Variants

1 paper

NM_000546.6

p.G187insFs

c.559_560insG

21 papers

NM_000546.6

p.G187Splc

c.559+2T>C

3 papers

NM_000546.6

p.G187Splc

c.559+2T>A

52 papers

NM_000546.6

p.G187Splc

c.559+1G>T

2 papers

NM_000546.6

p.G187Splc

c.559+3G>T

10 papers

NM_000546.6

p.G187Splc

c.559+1G>C

1 paper

NM_000546.6

p.G187Splc

c.559+3G>C

118 papers

NM_000546.6

p.G187Splc

c.559+1G>A

1 paper

NM_000546.6

p.V172_G187delFs

c.514_559del46

1 paper

NM_000546.6

p.D186_G187del1

c.557_559delCAT

1 paper

NM_000546.6

p.R181_G187delFs

c.543_559del17

1 paper

NM_000546.6

p.V172_G187del0

c.515_559del45