Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

34 papers

NM_000546.6

p.G187S

c.559G>A

Surrounding Variants

8 papers

NM_000546.6

p.G187C

c.559G>T

1 paper

NM_000546.6

p.D186insFs

c.558dupT

8 papers

NM_000546.6

p.G187R

c.559G>C

1 paper

NM_000546.6

p.S185_G187Fs

c.554_559delinsTFs

1 paper

NM_000546.6

p.S183_D186delFs

c.548_558del11

2 papers

NM_000546.6

p.D186insFs

c.557_558insA

1 paper

NM_000546.6

p.D186insFs

c.557_558ins5

1 paper

NM_000546.6

p.D186insFs

c.557_558ins17

11 papers

NM_000546.6

p.D186E

c.558T>G

4 papers

NM_000546.6

p.D186D

c.558T>C

12 papers

NM_000546.6

p.D186E

c.558T>A

2 papers

NM_000546.6

p.D186delFs

c.557delT