Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

128 papers

NM_000546.6

p.S183*

c.548C>G

Surrounding Variants

23 papers

NM_000546.6

p.S183L

c.548C>T

1 paper

NM_000546.6

p.S183ins7

c.548_549ins21

1 paper

NM_000546.6

p.R175_S183ins3

c.524_547dup24

127 papers

NM_000546.6

p.S183*

c.548C>A

1 paper

NM_000546.6

p.C182del1

c.544_545delGCA

1 paper

NM_000546.6

p.E180_S183delFs

c.538_547del10

1 paper

NM_000546.6

p.P177_C182ins2

c.529_546dup18

5 papers

NM_000546.6

p.S183A

c.547T>G

10 papers

NM_000546.6

p.S183P

c.547T>C

3 papers

NM_000546.6

p.S183T

c.547T>A

1 paper

NM_000546.6

p.C182delFs

c.545_546delGC

1 paper

NM_000546.6

p.C182_S183Fs

c.544_547delinsATGCCFs