Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.S183A

c.547T>G

Surrounding Variants

1 paper

NM_000546.6

p.P177_C182ins2

c.529_546dup18

10 papers

NM_000546.6

p.S183P

c.547T>C

3 papers

NM_000546.6

p.S183T

c.547T>A

1 paper

NM_000546.6

p.C182delFs

c.545_546delGC

1 paper

NM_000546.6

p.C182_S183Fs

c.544_547delinsATGCCFs

2 papers

NM_000546.6

p.R181_C182del2

c.541_545del6

1 paper

NM_000546.6

p.H179_C182delFs

c.536_546del11

49 papers

NM_000546.6

p.R174_E180del0

c.522_539del18

1 paper

NM_000546.6

p.E171_C182del12

c.511_545del36

4 papers

NM_000546.6

p.S183fs

c.547_548fs

23 papers

NM_000546.6

p.S183L

c.548C>T

1 paper

NM_000546.6

p.C182C

c.546C>T